THE DEFINITIVE GUIDE TO TRASTUZUMAB MONITORING

The phosphorylated HER3 provides docking websites for p85 subunit of PI3K. The completely activated PI3K sophisticated is generated by binding of p110 subunit of PI3K to p85 which has the capacity to make PIP3 through phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both equally threo